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Longitudinal trends show a fivedecade transition: from early underdiagnosis and limited therapeutics toward improved survival and broader symptom recognition, especially in highincome countries [43, 44, 45, 47, 48]

A systematic review published in the Cochrane Database found some evidence supporting antioxidant supplementation for male subfertility, though improvements in semen parameters do not necessarily translate to increased live birth rates

Both peptides enhance cellular antioxidant systemsGHK-CU through direct antioxidant activity and Epithalon through gene expression modulationprotecting against oxidative stress and age-related damage

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